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Article

Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation.

The Journal of biological chemistry - 27 Apr 2001

Ranganathan A C, Nelson K K, Rodriguez A M, Kim K H, Tower G B, Rutter J L, Brinckerhoff C E, Huang T T, Epstein C J, Jeffrey J J, Melendez J A

Abstract excerpt

Manganese-superoxide dismutase (Sod2) removes mitochondrially derived superoxide (O(2)) at near-diffusion limiting rates and is the only antioxidant enzyme whose expression is regulated by numerous stimuli. Here it is shown that Sod2 also serves as a source of the intracellular signaling molecule...

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Identifiers

PMID: 11297530
DOI: 10.1074/jbc.M100199200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11297530-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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