Article

Chronic ketosis provides neuroprotection through HIF-1α-mediated control of the TXNIP/NLRP3 axis by regulating the inflammatory and apoptotic response

2024-10-22

Abstract excerpt

<title>Abstract</title> <p>We and others have previously demonstrated that hypoxia-inducible factor alpha (HIF-1α) stabilization through diet-induced ketosis plays a vital role during brain ischemic injury. We have recently reported that ketosis-stabilized HIF-1α regulates the inflammatory response and contributes to neuroprotection in a rat stroke model. In the current investigation, we examined the downstream m...

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Literature Corpus work: b7aa833d-90a4-5587-ac35-89a8b648a68b
DOI: 10.21203/rs.3.rs-4914710/v1

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