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Article

Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy

12 May 2019

Abstract excerpt

Objective. Hypoxia is central in the pathogenesis of diabetic retinopathy (DR). Hypoxia-inducible factor-1 (HIF-1) is the key mediator in cellular oxygen homeostasis that facilitates the adaptation to hypoxia. HIF-1 is repressed by hyperglycemia contributing by this to the development of complications in diabetes. Recent work has shown that the HIF-1A Pro582Ser polymorphism is more resistant to...

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PMID: 31214621
DOI: 10.1155/2019/2936962

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