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Article

Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.

Science (New York, N.Y.) - 4 Jan 2002

Larsen Pamela L, Clarke Catherine F

Abstract excerpt

The isoprenylated benzoquinone coenzyme Q is a redox-active lipid essential for electron transport in aerobic respiration. Here, we show that withdrawal of coenzyme Q (Q) from the diet of wild-type nematodes extends adult life-span by approximately 60%. The longevity of clk-1, daf-2, daf-12, and daf-16 mutants is also extended by a Q-less diet. These results establish the importance of Q in life-span...

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PMID: 11778046
DOI: 10.1126/science.1064653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.PMID 11778046Read ↗

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