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Article

Sex-dependent compensated oxidative stress in the mouse liver upon deletion of catechol O-methyltransferase.

Biochemical pharmacology - 1 May 2009

Tenorio-Laranga Jofre, Männistö Pekka T, Karayiorgou Maria, Gogos Joseph A, García-Horsman J Arturo

Abstract excerpt

Catechol-O-methyl transferase (COMT) methylates catechols, such as L-dopa and dopamine, and COMT deficient mice show dramatic shifts in the metabolite levels of catechols. Increase in catechol metabolite levels can, in principle, lead to oxidative stress but no indices of oxidative stress have been reported in COMT-knockout (KO) mice [Forsberg MM, Juvonen RO, Helisalmi P, Leppanen J, Gogos JA, Karayiorgou M, et...

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Source

Identifiers

PMID: 19426692
DOI: 10.1016/j.bcp.2009.02.004

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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