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Article

Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLS-DA.

FEBS letters - 23 Oct 2002

Gavaghan C L, Wilson I D, Nicholson J K

Abstract excerpt

Metabolic phenotyping, or metabotyping, is increasingly being used as a probe in functional genomics studies. However, such profiling is subject to intrinsic physiological variation found in all animal populations. Using a nuclear magnetic resonance-based metabonomic approach, we show that diurnal variations in metabolism can obscure the interpretation of strain-related metabolic differences in two phenotypically...

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PMID: 12387891
DOI: 10.1016/s0014-5793(02)03476-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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