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Article

Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity.

The international journal of neuropsychopharmacology - 1 Oct 2014

Moskovitz Jackob, Walss-Bass Consuelo, Cruz Dianne A, Thompson Peter M, Bortolato Marco

Abstract excerpt

Catechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for attentional and cognitive deficits in both psychotic and healthy indi...

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Source

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Identifiers

PMID: 24735585
DOI: 10.1017/S1461145714000467
PMCID: PMC4398661

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24735585-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity.PMID 24735585Read ↗

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