Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.

Cancer research - 15 Sept 2001

Dawling S, Roodi N, Mernaugh R L, Wang X, Parl F F

Abstract excerpt

The oxidative metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and estrogen quinones has been postulated to be a factor in mammary carcinogenesis. Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

Share to Enzyme Stability

Share to Gas Chromatography-Mass Spectrometry

Share to Isoenzymes

Share to Methylation

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 11559542

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.PMID 11559542Read ↗

Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms.Semantic proximity Read ↗

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.Semantic proximity Read ↗

Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes.Semantic proximity Read ↗

Catechol-O-methyltransferase Val 108/158 Met polymorphism in premenopausal breast cancer patients.Semantic proximity Read ↗

Influence of the catechol-O-methyltransferase (COMT) codon 158 polymorphism on estrogen levels in women.Semantic proximity Read ↗

The Val158Met polymorphism in COMT gene and cancer risk: role of endogenous and exogenous catechols.Semantic proximity Read ↗

Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan.Semantic proximity Read ↗

Catecholestrogens induce oxidative stress and malignant transformation in human endometrial glandular cells: Protective effect of catechol‐<i>O</i>‐methyltransferaseSemantic proximity Read ↗

Catechol-O-Methyltransferase (COMT) gene polymorphism and breast cancer risk in young women.Semantic proximity Read ↗

Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulatorSemantic proximity Read ↗

Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in postmenopausal women: a meta-analysis.Semantic proximity Read ↗

Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.