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Article

Catechol O-methyltransferase pharmacogenetics: photoaffinity labelling and western blot analysis of human liver samples.

Pharmacogenetics - 1 Apr 1993

Aksoy S, Klener J, Weinshilboum R M

Abstract excerpt

The level of catechol O-methyltransferase (COMT) activity and COMT thermal stability in human tissue are controlled by a common genetic polymorphism. We studied individual hepatic biopsy samples shown previously to have phenotypically high, low or intermediate COMT activities and thermal stabilities to test the hypothesis that the molecular mass (M(r)) and/or isoelectric point (pI) of the enzyme might differ in...

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Identifiers

PMID: 8518836
DOI: 10.1097/00008571-199304000-00008

Genes

COMT
SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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