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Article

Resistance to salt-induced hypertension in catechol-O-methyltransferase-gene-disrupted mice.

Journal of hypertension - 1 Dec 2003

Helkamaa Teemu, Männistö Pekka T, Rauhala Pekka, Cheng Zhong Jian, Finckenberg Piet, Huotari Marko, Gogos Joseph A, Karayiorgou Maria, Mervaala Eero M

Abstract excerpt

BACKGROUND: Previous studies have indicated that catechol-O-methyltransferase (COMT) can modulate renal dopaminergic tone. OBJECTIVE: To test the hypothesis that COMT blockade protects from salt-induced hypertension. METHODS: COMT gene-disrupted (-/-) mice and wild-type controls received a high-sodium diet (NaCl 6%) for 3 weeks. Blood pressure and heart rate were recorded by radiotelemetry. Tissue and urine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14654758
DOI: 10.1097/00004872-200312000-00026

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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