Article
Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity.
Gene - 1 Apr 2012
Hiyoshi Mineyoshi, Uemura Hirokazu, Arisawa Kokichi, Nakamoto Mariko, Hishida Asahi, Okada Rieko, Matsuo Keitaro, Kita Yoshikuni, Niimura Hideshi, Kuriyama Nagato, Nanri Hinako, Ohnaka Keizo, Suzuki Sadao, Mikami Haruo, Kubo Michiaki, Tanaka Hideo, Hamajima Nobuyuki
Abstract excerpt
In our previous proteomic study in rat liver damaged by carbon tetrachloride, soluble catechol-O-methyltransferase (COMT) increased as a phosphorylated form and decreased as a dephosphorylated form. This finding raised the possibility that the COMT protein is associated with liver function. Thus, we hypothesized that (1) the COMT gene contributes to liver homeostasis and (2) a COMT polymorphism (rs4680:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.