Article
Sequence variation and expression of the Gimap gene family in the BB rat.
Experimental diabetes research - 1 Jan 2009
Rutledge Elizabeth A, Fuller Jessica M, Van Yserloo Brian, Moralejo Daniel H, Ettinger Ruth A, Gaur Prashant, Hoehna Jana L, Peterson Morgan R, Jensen Richard, Kwitek Anne E, Lernmark Ake
Abstract excerpt
Positional cloning of lymphopenia (lyp) in the BB rat revealed a frameshift mutation in Gimap5, a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR.lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR...
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