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Unfolded protein responses in T cell immunity

8 Jan 2025

Abstract excerpt

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are integral to T cell biology, influencing immune responses and associated diseases. This review explores the interplay between the UPR and T cell immunity, highlighting the role of these cellular processes in T cell activation, differentiation, and function. The UPR, mediated by IRE1, PERK, and ATF6, is crucial for maintaining ER...

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PMID: 39845962
DOI: 10.3389/fimmu.2024.1515715

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