Article

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002-02-15

Abstract excerpt

Overload of pancreatic β cells in conditions such as hyperglycemia, obesity, and long-term treatment with sulfonylureas leads to β cell exhaustion and type 2 diabetes. Because β cell mass declines under these conditions, apparently as a result of apoptosis, we speculated that overload kills β cells as a result of endoplasmic reticulum (ER) stress. The Akita mouse, which carries a conformation-altering missense mut...

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Literature Corpus work: 8c4bd733-87f5-5a0f-8088-bd4b82db8866
DOI: 10.1172/jci200214550

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