Article
Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK.
Diabetes - 1 Apr 2005
Ladiges Warren C, Knoblaugh Sue E, Morton John F, Korth Marcus J, Sopher Bryce L, Baskin Carole R, MacAuley Alasdair, Goodman Alan G, LeBoeuf Renee C, Katze Michael G
Abstract excerpt
The endoplasmic reticulum (ER) transmits apoptotic signals in the pancreas during ER stress, implicating ER stress-mediated apoptosis in the development of diabetes. P58(IPK) (DNAJC3) is induced during ER stress and functions as a negative feedback component to inhibit eIF-2alpha signaling and attenuate the later phases of the ER stress response. To gain insight into a more comprehensive role of P58(IPK)...
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