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Article

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome.

PloS one - 1 Jan 2016

Rossi Danuza, Barbosa Natalia M, Galvão Fabio C, Boldrin Paulo E G, Hershey John W B, Zanelli Cleslei F, Fraser Christopher S, Valentini Sandro R

Abstract excerpt

eIF5A is the only protein known to contain the essential and unique amino acid residue hypusine. eIF5A functions in both translation initiation due to its stimulation of methionyl-puromycin synthesis and translation elongation, being highly required for peptide-bound formation of specific ribosome stalling sequences such as poly-proline. The functional interaction between eIF5A, tRNA, and eEF2 on the surface of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27115996
DOI: 10.1371/journal.pone.0154205
PMCID: PMC4845985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome.PMID 27115996Read ↗

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