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Article

Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification.

The FEBS journal - 1 Jan 2008

Cano Veridiana S P, Jeon Geoung A, Johansson Hans E, Henderson C Allen, Park Jong-Hwan, Valentini Sandro R, Hershey John W B, Park Myung Hee

Abstract excerpt

The eukaryotic translation initiation factor 5A (eIF5A) is the only protein that contains hypusine [Nepsilon-(4-amino-2-hydroxybutyl)lysine], which is required for its activity. Hypusine is formed by post-translational modification of one specific lysine (Lys50 for human eIF5A) by deoxyhypusine synthase and deoxyhypusine hydroxylase. To investigate the features of eIF5A required for its activity, we generated 49...

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Identifiers

PMID: 18067580
DOI: 10.1111/j.1742-4658.2007.06172.x
PMCID: PMC2536608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification.PMID 18067580Read ↗

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