Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway.

doi:10.1074/jbc.M601460200

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway.

The Journal of biological chemistry - 17 Nov 2006

Schrader Rainer, Young Craig, Kozian Detlef, Hoffmann Reinhard, Lottspeich Friedrich

Abstract excerpt

The highly conserved protein eIF5A found in Archaea and all eukaryotes uniquely contains the posttranslationally formed amino acid hypusine. Despite being essential the functions of this protein and its modification remain unclear. To gain more insight into these functions temperature-sensitive mutants of the human EIF5A1 were characterized in the yeast Saccharomyces cerevisiae. Expression of the point mutated...

Topics

Humans
Mutation
Peptide Initiation Factors
RNA Stability
RNA, Messenger
RNA-Binding Proteins
Saccharomyces cerevisiae
Temperature
Eukaryotic Translation Initiation Factor 5A

Source

Open in PubMed

Identifiers

PMID: 16987817
DOI: 10.1074/jbc.M601460200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics