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Article

Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jun 1991

Schnier J, Schwelberger H G, Smit-McBride Z, Kang H A, Hershey J W

Abstract excerpt

Translation intitiation factor eIF-5A (previously named eIF-4D) is a highly conserved protein that promotes formation of the first peptide bond. One of its lysine residues is modified by spermidine to form hypusine, a posttranslational modification unique to eIF-5A. To elucidate the function of eIF-5A and determine the role of its hypusine modification, the cDNA encoding human eIF-5A was used as a probe to...

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Identifiers

PMID: 1903841
DOI: 10.1128/mcb.11.6.3105-3114.1991
PMCID: PMC360154

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Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.PMID 1903841Read ↗

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Structural modeling and mutational analysis of yeast eukaryotic translation initiation factor 5A reveal new critical residues and reinforce its involvement in protein synthesis.Semantic proximity Read ↗

Hypusine-containing protein eIF5A promotes translation elongation.Semantic proximity Read ↗

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eIF5A is an indispensable protein for eukaryotic cellsSemantic proximity Read ↗

Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling.Semantic proximity Read ↗

Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway.Semantic proximity Read ↗

Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification.Semantic proximity Read ↗

Characterization of translation initiation factor 5 (eIF5) from Saccharomyces cerevisiae. Functional homology with mammalian eIF5 and the effect of depletion of eIF5 on protein synthesis in vivo and in vitro.Semantic proximity Read ↗

Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex.Semantic proximity Read ↗

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