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Article

Ultra-deep sequencing improves the detection of drug resistance in cellular DNA from HIV-infected patients on ART with suppressed viraemia.

The Journal of antimicrobial chemotherapy - 1 Nov 2018

Rodriguez Christophe, Nere Marie Laure, Demontant Vanessa, Charreau Isabelle, Mercier-Darty Mélanie, Delagreverie Héloïse, Salmona Maud, de Castro Nathalie, Chaix Marie Laure, Molina Jean Michel, Delaugerre Constance

Abstract excerpt

Background: Standard genotypic tests performed on HIV DNA from patients on suppressive ART, with previous resistance-associated mutations (RAMs) detected in their plasma, underestimate resistance. We thus compared ultra-deep sequencing (UDS) with bulk sequencing of DNA to detect RAMs previously identified in plasma. Methods: We sequenced the DNA of 169 highly treatment experienced patients with suppressed...

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PMID: 30137335
DOI: 10.1093/jac/dky315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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