Article
Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing.
BMC infectious diseases - 30 Jan 2013
Bansode Vijay, McCormack Grace P, Crampin Amelia C, Ngwira Bagrey, Shrestha Ram K, French Neil, Glynn Judith R, Travers Simon A
Abstract excerpt
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize the genetic diversity and evolution of HIV drug resistant variants in an individual's provirus during antiretroviral therapy using next generation sequencing....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.