Article
Structural insights into eRF3 and stop codon recognition by eRF1.
Genes & development - 1 May 2009
Cheng Zhihong, Saito Kazuki, Pisarev Andrey V, Wada Miki, Pisareva Vera P, Pestova Tatyana V, Gajda Michal, Round Adam, Kong Chunguang, Lim Mengkiat, Nakamura Yoshikazu, Svergun Dmitri I, Ito Koichi, Song Haiwei
Abstract excerpt
Eukaryotic translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act cooperatively to ensure efficient stop codon recognition and fast polypeptide release. The crystal structures of human and Schizosaccharomyces pombe full-length eRF1 in complex with eRF3 lacking the GTPase domain revealed details of the interaction between these two factors and marked conformational changes...
Topics
- Adenosine Triphosphate
- Codon, Terminator
- GTP Phosphohydrolases
- Gene Order
- Humans
- Models, Molecular
- Mutation
- Peptide Termination Factors
- Protein Binding
- Protein Biosynthesis