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Article

Two-step model of stop codon recognition by eukaryotic release factor eRF1.

Nucleic acids research - 1 Apr 2013

Kryuchkova Polina, Grishin Alexander, Eliseev Boris, Karyagina Anna, Frolova Ludmila, Alkalaeva Elena

Abstract excerpt

Release factor eRF1 plays a key role in the termination of protein synthesis in eukaryotes. The eRF1 consists of three domains (N, M and C) that perform unique roles in termination. Previous studies of eRF1 point mutants and standard/variant code eRF1 chimeras unequivocally demonstrated a direct involvement of the highly conserved N-domain motifs (NIKS, YxCxxxF and GTx) in stop codon recognition. In the current...

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Identifiers

PMID: 23435318
DOI: 10.1093/nar/gkt113
PMCID: PMC3632111

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Source receipt: pubmed, retrieved 7 Sept 2026.

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