Two-step model of stop codon recognition by eukaryotic release factor eRF1.

doi:10.1093/nar/gkt113

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Article

Two-step model of stop codon recognition by eukaryotic release factor eRF1.

Nucleic acids research - 1 Apr 2013

Kryuchkova Polina, Grishin Alexander, Eliseev Boris, Karyagina Anna, Frolova Ludmila, Alkalaeva Elena

Abstract excerpt

Release factor eRF1 plays a key role in the termination of protein synthesis in eukaryotes. The eRF1 consists of three domains (N, M and C) that perform unique roles in termination. Previous studies of eRF1 point mutants and standard/variant code eRF1 chimeras unequivocally demonstrated a direct involvement of the highly conserved N-domain motifs (NIKS, YxCxxxF and GTx) in stop codon recognition. In the current...

Topics

Amino Acid Sequence
Codon, Terminator
Humans
Models, Molecular
Molecular Sequence Data
Mutation
Peptide Chain Termination, Translational
Peptide Termination Factors
Peptides
Protein Structure, Tertiary
Ribosomes
Sequence Alignment

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Identifiers

PMID: 23435318
DOI: 10.1093/nar/gkt113
PMCID: PMC3632111

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