Article
Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe.
Molecular cell - 23 Apr 2004
Kong Chunguang, Ito Koichi, Walsh Martin A, Wada Miki, Liu Yuying, Kumar Sundramurthy, Barford David, Nakamura Yoshikazu, Song Haiwei
Abstract excerpt
Translation termination in eukaryotes is governed by two interacting release factors, eRF1 and eRF3. The crystal structure of the eEF1alpha-like region of eRF3 from S. pombe determined in three states (free protein, GDP-, and GTP-bound forms) reveals an overall structure that is similar to EF-Tu, although with quite different domain arrangements. In contrast to EF-Tu, GDP/GTP binding to eRF3c does not induce...
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