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Article

The role of N-terminal domain of translational release factor eRF3 for the control of functionality and stability in S. cerevisiae.

Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2007

Kodama Hiroyuki, Ito Koichi, Nakamura Yoshikazu

Abstract excerpt

Translation termination in eukaryotes is mediated by two eukaryotic release factors, eRF1 and eRF3. eRF1 recognizes all three stop codons and induces polypeptide release, while eRF3 binds to eRF1 and participates in translation termination though the regulatory role of eRF3 is still unknown. Importantly, eRF3 interacts with various proteins of distinct biological functions. Here, we investigated the effect of...

Topics

Carrier Proteins
Cytoskeletal Proteins
Drug Stability
Genes, Fungal
Models, Molecular
Mutation
Peptide Termination Factors
Phenotype
Protein Binding
Protein Structure, Tertiary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Temperature

Source

Identifiers

PMID: 17535254
DOI: 10.1111/j.1365-2443.2007.01082.x

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The role of N-terminal domain of translational release factor eRF3 for the control of functionality and stability in S. cerevisiae.PMID 17535254Read ↗

N-terminal region of Saccharomyces cerevisiae eRF3 is essential for the functioning of the eRF1/eRF3 complex beyond translation termination.Semantic proximity Read ↗

Identification of translational release factor eRF1a binding sites on eRF3 in Euplotes octocarinatus.Semantic proximity Read ↗

N-terminal extension of Saccharomyces cerevisiae translation termination factor eRF3 influences the suppression efficiency of sup35 mutations.Semantic proximity Read ↗

The C-terminus of eRF1 defines a functionally important domain for translation termination in Saccharomyces cerevisiae.Semantic proximity Read ↗

Structural insights into eRF3 and stop codon recognition by eRF1.Semantic proximity Read ↗

C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction.Semantic proximity Read ↗

Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe.Semantic proximity Read ↗

Eukaryotic release factor 3 is required for multiple turnovers of peptide release catalysis by eukaryotic release factor 1.Semantic proximity Read ↗

A novel mutant of the Sup35 protein of Saccharomyces cerevisiae defective in translation termination and in GTPase activity still supports cell viability.Semantic proximity Read ↗

A genetic approach for analyzing the co-operative function of the tRNA mimicry complex, eRF1/eRF3, in translation termination on the ribosome.Semantic proximity Read ↗

GTP hydrolysis by eRF3 facilitates stop codon decoding during eukaryotic translation termination.Semantic proximity Read ↗

Molecular dissection of translation termination mechanism identifies two new critical regions in eRF1.Semantic proximity Read ↗

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