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Article

14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4.

The Journal of biological chemistry - 17 Jul 2009

Silhan Jan, Vacha Petr, Strnadova Pavla, Vecer Jaroslav, Herman Petr, Sulc Miroslav, Teisinger Jan, Obsilova Veronika, Obsil Tomas

Abstract excerpt

The role of 14-3-3 proteins in the regulation of FOXO forkhead transcription factors is at least 2-fold. First, the 14-3-3 binding inhibits the interaction between the FOXO and the target DNA. Second, the 14-3-3 proteins prevent nuclear reimport of FOXO factors by masking their nuclear localization signal. The exact mechanisms of these processes are still unclear, mainly due to the lack of structural data. In...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19416966
DOI: 10.1074/jbc.M109.002725
PMCID: PMC2740560

Genes

FOXO4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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