Article

Oncogenic mutations in the DNA-binding domain of FOXO1 disrupt folding: quantitative insights from experiments and molecular simulations

2022-04-02

Abstract excerpt

FOXO1, a member of the family of winged-helix motif Forkhead box (FOX) transcription factors, is the most abundantly expressed FOXO member in mature B-cells. Sequencing of diffuse large B-cell lymphoma (DLBCL) tumors and cell lines identified specific mutations in the forkhead domain linked to loss of function. Differential scanning calorimetry and thermal shift assays were used to characterize how eight of these...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 00dc14ce-9447-51e4-971b-ed80da189970
DOI: 10.1101/2022.04.01.486713

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oncogenic mutations in the DNA-binding domain of FOXO1 disrupt folding: quantitative insights from experiments and molecular simulationsDOI 10.1101/2022.04.01.486713Read

Oncogenic Mutations in the DNA-Binding Domain of FOXO1 that Disrupt Folding: Quantitative Insights from Experiments and Molecular Simulations.Semantic proximity Read

Disclosing the Impact of Carcinogenic SF3b Mutations on Pre-mRNA Recognition Via All-Atom Simulations.Semantic proximity Read

Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations.Semantic proximity Read

Pathogenic <i>BRCA1</i> mutations disrupt allosteric control by <i>BARD1</i>Semantic proximity Read

Transient Unfolding and Long-Range Interactions in Viral BCL2 M11 Enable Binding to the BECN1 BH3 Domain.Semantic proximity Read

Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculationsSemantic proximity Read

Examining Genetic Variants Associated with FOXP1 Syndrome through Molecular Dynamics of Its DNA-Binding Domain and Self-Organizing Maps.Semantic proximity Read

Potts Hamiltonian Models and Molecular Dynamics Free Energy Simulations for Predicting the Impact of Mutations on Protein Kinase Stability.Semantic proximity Read

Allosteric effects in the marginally stable von Hippel-Lindau tumor suppressor protein and allostery-based rescue mutant design.Semantic proximity Read

Three-Dimensional Domain Swapping Changes the Folding Mechanism of the Forkhead Domain of FoxP1.Semantic proximity Read

Non-Markovian Dynamic Models Identify Non-Canonical KRAS-VHL Encounter Complex Conformations for Novel PROTAC DesignSemantic proximity Read

Modulating the DNA affinity of Elk-1 with computationally selected mutations.Semantic proximity Read