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Article

Oncogenic Mutations in the DNA-Binding Domain of FOXO1 that Disrupt Folding: Quantitative Insights from Experiments and Molecular Simulations.

Biochemistry - 16 Aug 2022

Novack Dylan, Qian Lei, Acker Gwyneth, Voelz Vincent A, Baxter Richard H G

Abstract excerpt

FOXO1, a member of the family of winged-helix motif Forkhead box (FOX) transcription factors, is the most abundantly expressed FOXO member in mature B cells. Sequencing of diffuse large B-cell lymphoma (DLBCL) tumors and cell lines identified specific mutations in the forkhead domain linked to loss of function. Differential scanning calorimetry and thermal shift assays were used to characterize how eight of these...

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PMID: 35895105
DOI: 10.1021/acs.biochem.2c00224
PMCID: PMC9482095

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