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Article

Structural Analysis of the 14-3-3ζ/Chibby Interaction Involved in Wnt/β-Catenin Signaling.

PloS one - 1 Jan 2015

Killoran Ryan C, Fan Jingsong, Yang Daiwen, Shilton Brian H, Choy Wing-Yiu

Abstract excerpt

The partially disordered Chibby (Cby) is a conserved nuclear protein that antagonizes the Wnt/β-catenin signaling pathway. By competing with the Tcf/Lef family proteins for binding to β-catenin, Cby abrogates the β-catenin-mediated transcription of Wnt signaling genes. Additionally, upon phosphorylation on S20 by the kinase Akt, Cby forms a complex with 14-3-3 to facilitate the nuclear export of β-catenin, which...

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Identifiers

PMID: 25909186
DOI: 10.1371/journal.pone.0123934
PMCID: PMC4409382

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