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Article

Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA binding.

Protein science : a publication of the Protein Society - 1 May 2011

Chu Yuan-Ping, Chang Chia-Hao, Shiu Jia-Hau, Chang Yao-Tsung, Chen Chiu-Yueh, Chuang Woei-Jer

Abstract excerpt

FOXP1 belongs to the P-subfamily of forkhead transcription factors and contains a conserved forkhead DNA-binding domain. According to size exclusion chromatography analysis, the forkhead domain of FOXP1 existed as a mixture of monomer and dimer. The dissociation constants of the forkhead domain of wild-type, C61S, and C61Y mutants of FOXP1 were 27.3, 28.8, and 332.0 μM, respectively. In contrast, FOXP1 A39P...

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Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Multimerization

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Source

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Identifiers

PMID: 21416545
DOI: 10.1002/pro.626
PMCID: PMC3125874

Genes

FOXP1
FOXP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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