Article
Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.
The Journal of experimental medicine - 11 May 2009
Keele Brandon F, Li Hui, Learn Gerald H, Hraber Peter, Giorgi Elena E, Grayson Truman, Sun Chuanxi, Chen Yalu, Yeh Wendy W, Letvin Norman L, Mascola John R, Nabel Gary J, Haynes Barton F, Bhattacharya Tanmoy, Perelson Alan S, Korber Bette T, Hahn Beatrice H, Shaw George M
Abstract excerpt
We recently developed a novel strategy to identify transmitted HIV-1 genomes in acutely infected humans using single-genome amplification and a model of random virus evolution. Here, we used this approach to determine the molecular features of simian immunodeficiency virus (SIV) transmission in 18 experimentally infected Indian rhesus macaques. Animals were inoculated intrarectally (i.r.) or intravenously (i.v.)...
Topics
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Animals
- Antibodies, Viral
- CD4-Positive T-Lymphocytes
- Disease Models, Animal
- Evolution, Molecular
- Genes, Viral
- Genes, env