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Article

A limited number of simian immunodeficiency virus (SIV) env variants are transmitted to rhesus macaques vaginally inoculated with SIVmac251.

Journal of virology - 1 Jul 2010

Stone Mars, Keele Brandon F, Ma Zhong-Min, Bailes Elizabeth, Dutra Joseph, Hahn Beatrice H, Shaw George M, Miller Christopher J

Abstract excerpt

Single-genome amplification (SGA) and sequencing of HIV-1 RNA in plasma of acutely infected humans allows the identification and enumeration of transmitted/founder viruses responsible for productive systemic infection. Use of this strategy as a means for identifying transmitted viruses suggested that intrarectal simian immunodeficiency virus (SIV) inoculation of macaques recapitulates key features of human rectal...

Topics

Animals
Female
Gene Products, env
Genetic Variation
Humans
Macaca mulatta
Protein Isoforms
RNA, Viral
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vagina

Source

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Identifiers

PMID: 20463069
DOI: 10.1128/JVI.00481-10
PMCID: PMC2898254

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