Article
A limited number of simian immunodeficiency virus (SIV) env variants are transmitted to rhesus macaques vaginally inoculated with SIVmac251.
Journal of virology - 1 Jul 2010
Stone Mars, Keele Brandon F, Ma Zhong-Min, Bailes Elizabeth, Dutra Joseph, Hahn Beatrice H, Shaw George M, Miller Christopher J
Abstract excerpt
Single-genome amplification (SGA) and sequencing of HIV-1 RNA in plasma of acutely infected humans allows the identification and enumeration of transmitted/founder viruses responsible for productive systemic infection. Use of this strategy as a means for identifying transmitted viruses suggested that intrarectal simian immunodeficiency virus (SIV) inoculation of macaques recapitulates key features of human rectal...
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