Article
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection.
Proceedings of the National Academy of Sciences of the United States of America - 27 May 2008
Keele Brandon F, Giorgi Elena E, Salazar-Gonzalez Jesus F, Decker Julie M, Pham Kimmy T, Salazar Maria G, Sun Chuanxi, Grayson Truman, Wang Shuyi, Li Hui, Wei Xiping, Jiang Chunlai, Kirchherr Jennifer L, Gao Feng, Anderson Jeffery A, Ping Li-Hua, Swanstrom Ronald, Tomaras Georgia D, Blattner William A, Goepfert Paul A, Kilby J Michael, Saag Michael S, Delwart Eric L, Busch Michael P, Cohen Myron S, Montefiori David C, Haynes Barton F, Gaschen Brian, Athreya Gayathri S, Lee Ha Y, Wood Natasha, Seoighe Cathal, Perelson Alan S, Bhattacharya Tanmoy, Korber Bette T, Hahn Beatrice H, Shaw George M
Abstract excerpt
The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 transmission and in designing effective vaccines. Here, we developed a mathematical model of random viral evolution and, together with phylogenetic tree construction, used it to analyze 3,449 complete env sequences derived by single...
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