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Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants

20 Feb 2023

Abstract excerpt

The decay kinetics of HIV-1-infected cells are critical to understand virus persistence. We evaluated the frequency of simian immunodeficiency virus (SIV)-infected cells for 4 years of antiretroviral therapy (ART). The intact proviral DNA assay (IPDA) and an assay for hypermutated proviruses revealed short- and long-term infected cell dynamics in macaques starting ART ∼1 year after infection. Intact SIV genomes...

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PMID: 36809762
DOI: 10.1016/j.chom.2023.01.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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