Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in the fibrinogen-alpha and fibrinogen-gamma genes in relation to arterial stiffness: the Rotterdam Study.

Journal of hypertension - 1 Jul 2009

Sie Mark P S, Isaacs Aaron, de Maat Moniek P M, Mattace-Raso Francesco U S, Uitterlinden André G, Kardys Isabella, Hofman Albert, Hoeks Arnold P G, Reneman Robert S, van Duijn Cornelia M, Witteman Jaqueline C M

Abstract excerpt

OBJECTIVE: Arterial stiffness increases with age and predicts cardiovascular disease. Fibrinogen is an acute-phase protein and some studies showed an association with arterial stiffness. We studied genetic variation in the fibrinogen-alpha (FGA) and fibrinogen-gamma (FGG) genes, by means of single nucleotide polymorphisms (FGA: -58 G/A, 1374 G/A, 1526 T/C, 312 Thr/Ala, and FGG: 4288 G/A, 6326 G/A, 7792 T/C) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Arteries

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrinogen

Share to FGG gene

Share to Genetic Variation

Share to Genotype

Share to Haplotypes

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 19412134
DOI: 10.1097/HJH.0b013e32832a95b0

Genes

FGA
FGG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in the fibrinogen-alpha and fibrinogen-gamma genes in relation to arterial stiffness: the Rotterdam Study.PMID 19412134Read ↗

Association study between variants in the fibrinogen gene cluster, fibrinogen levels and hypertension: results from the MONICA/KORA study.Semantic proximity Read ↗

Genes encoding fibrinogen and cardiovascular risk.Semantic proximity Read ↗

Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.Semantic proximity Read ↗

Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study.Semantic proximity Read ↗

Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: the Rotterdam Study.Semantic proximity Read ↗

TGF-beta1 polymorphisms and arterial stiffness; the Rotterdam Study.Semantic proximity Read ↗

Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study.Semantic proximity Read ↗

Genetics and pathophysiology of arterial stiffness.Semantic proximity Read ↗

Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study.Semantic proximity Read ↗

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.Semantic proximity Read ↗

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.Semantic proximity Read ↗

A multilocus genetic risk score is associated with arterial stiffness in hypertensive patients: the CARE NORTH study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.