Article
Genetics and pathophysiology of arterial stiffness.
Cardiovascular research - 1 Mar 2009
Lacolley Patrick, Challande Pascal, Osborne-Pellegrin Mary, Regnault Veronique
Abstract excerpt
Arterial stiffness is a cardiovascular risk factor that is independent of arterial pressure. Clinically, carotid-femoral pulse wave velocity (PWV) is the gold-standard parameter of arterial stiffness. Recent genetic studies have revealed specific genes that contribute to arterial stiffening. Here we review the recent findings on genome-wide linkage analyses and candidate gene polymorphism association studies. We...
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