Article
Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies.
Journal of hypertension - 1 Jul 2009
Engelen Lian, Ferreira Isabel, Brouwers Olaf, Henry Ronald M A, Dekker Jacqueline M, Nijpels Giel, Heine Robert J, van Greevenbroek Marleen M J, van der Kallen Carla J H, Blaak Ellen E, Feskens Edith J M, ten Cate Hugo, Stehouwer Coen D A, Schalkwijk Casper G
Abstract excerpt
OBJECTIVES: Methylglyoxal is a major precursor in the formation of advanced glycation endproducts (AGEs), which are known to contribute to vascular complications such as hypertension and arterial stiffness. Methylglyoxal can be detoxified by glyoxalase 1 (GLO1). Because genetic variation in the GLO1 gene may alter the expression and/or the activity of GLO1, we investigated whether single nucleotide polymorphisms...
Topics
- Aged
- Blood Pressure
- Cohort Studies
- Cross-Sectional Studies
- Glycation End Products, Advanced
- Humans
- Lactoylglutathione Lyase
- Middle Aged
- Polymorphism, Single Nucleotide
- Vascular Diseases