Common variants in glyoxalase I do not increase chronic pancreatitis risk.

doi:10.1371/journal.pone.0222927

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Article

Common variants in glyoxalase I do not increase chronic pancreatitis risk.

PloS one - 1 Jan 2019

Kaune Tom, Hollenbach Marcus, Keil Bettina, Chen Jian-Min, Masson Emmanuelle, Becker Carla, Damm Marko, Ruffert Claudia, Grützmann Robert, Hoffmeister Albrecht, Te Morsche Rene H M, Cavestro Giulia Martina, Zuppardo Raffaella Alessia, Saftoiu Adrian, Malecka-Panas Ewa, Głuszek Stanislaw, Bugert Peter, Lerch Markus M, Weiss Frank Ulrich, Zou Wen-Bin, Liao Zhuan, Hegyi Peter, Drenth Joost Ph, Riedel Jan, Férec Claude, Scholz Markus, Kirsten Holger, Tóth Andrea, Ewers Maren, Witt Heiko, Griesmann Heidi, Michl Patrick, Rosendahl Jonas

Abstract excerpt

INTRODUCTION: Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE). Methylglyoxal is detoxified by Glyoxalase I (GLO1). A reduction in GLO1 activity results in increased ROS. Single nucleotide polymorphisms (SNPs) of GLO1 have been linked to various inflammatory diseases....

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PMID: 31661534
DOI: 10.1371/journal.pone.0222927
PMCID: PMC6818803

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