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Article

The characterisation and functional analysis of the human glyoxalase-1 gene using methods of bioinformatics.

Gene - 13 Oct 2004

Gale Christopher P, Grant Peter J

Abstract excerpt

Methylglyoxal (MG), which forms MG-derived AGE, is elevated in diabetic subjects with vascular disease. Detoxification of MG occurs through the glyoxalase system incorporating glyoxalase-1 (GLO1) and glyoxalase-2. Perturbations of the glyoxalase-1 gene (GLO1) may result in vulnerability to vascular complications through alterations in AGE interactions. We used bioinformatics to predict the structure, function and...

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Source

Identifiers

PMID: 15475166
DOI: 10.1016/j.gene.2004.07.009

Genes

GLO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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