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Identification of glyoxalase 1 polymorphisms associated with enzyme activity.

Gene - 15 Feb 2013

Peculis Raitis, Konrade Ilze, Skapare Elina, Fridmanis Davids, Nikitina-Zake Liene, Lejnieks Aivars, Pirags Valdis, Dambrova Maija, Klovins Janis

Abstract excerpt

The glyoxalase system and its main enzyme, glyoxalase 1 (GLO1), protect cells from advanced glycation end products (AGEs), such as methylglyoxal (MG) and other reactive dicarbonyls, the formation of which is increased in diabetes patients as a result of excessive glycolysis. MG is partly responsible for harmful protein alterations in living cells, notably in neurons, leading to their dysfunction, and recent...

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Source

Identifiers

PMID: 23201419
DOI: 10.1016/j.gene.2012.11.009

Genes

GLO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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