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Article

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}.

The Journal of biological chemistry - 10 Jul 2009

Zhao Wei-Qin, Lacor Pascale N, Chen Hui, Lambert Mary P, Quon Michael J, Krafft Grant A, Klein William L

Abstract excerpt

Accumulation of amyloid beta (Abeta) oligomers in the brain is toxic to synapses and may play an important role in memory loss in Alzheimer disease. However, how these toxins are built up in the brain is not understood. In this study we investigate whether impairments of insulin and insulin-like...

Topics

Amyloid beta-Peptides
Animals
Antigens, CD
Brain
Humans
Insulin
Insulin Resistance
Insulin-Like Growth Factor I
Mice
Models, Biological
Mutation
NIH 3T3 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

Neurotoxins

Rats

Receptor, Insulin

Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 19406747
DOI: 10.1074/jbc.M109.011015
PMCID: PMC2707198

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-19406747-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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