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Article

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}.

The Journal of biological chemistry - 10 Jul 2009

Zhao Wei-Qin, Lacor Pascale N, Chen Hui, Lambert Mary P, Quon Michael J, Krafft Grant A, Klein William L

Abstract excerpt

Accumulation of amyloid beta (Abeta) oligomers in the brain is toxic to synapses and may play an important role in memory loss in Alzheimer disease. However, how these toxins are built up in the brain is not understood. In this study we investigate whether impairments of insulin and insulin-like growth factor-1 (IGF-1) receptors play a role in aggregation of Abeta. Using primary neuronal culture and immortal cell...

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Identifiers

PMID: 19406747
DOI: 10.1074/jbc.M109.011015
PMCID: PMC2707198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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