Article
Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease.
Neurology - 23 May 2006
Kulstad J J, Green P S, Cook D G, Watson G S, Reger M A, Baker L D, Plymate S R, Asthana S, Rhoads K, Mehta P D, Craft S
Abstract excerpt
BACKGROUND: Hyperinsulinemia and insulin resistance are risk factors for memory impairment and Alzheimer disease (AD). Insulin regulates levels of the amyloid beta-peptide (Abeta) in vitro in neuronal cultures and in vivo in the CSF of normal older adults. OBJECTIVE: To determine whether insulin affected plasma Abeta levels and whether such effects differed for patients with AD compared with normal older adults....
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