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Article

Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease.

Molecular neurobiology - 1 Apr 2019

Barone Eugenio, Tramutola Antonella, Triani Francesca, Calcagnini Silvio, Di Domenico Fabio, Ripoli Cristian, Gaetani Silvana, Grassi Claudio, Butterfield D Allan, Cassano Tommaso, Perluigi Marzia

Abstract excerpt

Impairment of biliverdin reductase-A (BVR-A) is an early event leading to brain insulin resistance in AD. Intranasal insulin (INI) administration is under evaluation as a strategy to alleviate brain insulin resistance; however, the molecular mechanisms underlying INI beneficial effects are still unclear. We show that INI improves insulin signaling activation in the hippocampus and cortex of adult and aged 3×Tg-AD...

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Identifiers

PMID: 30073505
DOI: 10.1007/s12035-018-1231-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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