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Article

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine.

Journal of Alzheimer's disease : JAD - 1 Dec 2005

Rivera Enrique J, Goldin Alison, Fulmer Noah, Tavares Rose, Wands Jack R, de la Monte Suzanne M

Abstract excerpt

Reduced glucose utilization and energy metabolism occur early in the course of Alzheimer's disease (AD) and correlate with impaired cognition. Glucose utilization and energy metabolism are regulated by insulin and insulin-like growth factor I (IGF-I), and correspondingly, studies have shown that cognitive impairment may be improved by glucose or insulin administration. Recently, we demonstrated significantly...

Topics

Acetylcholine
Aged
Aged, 80 and over
Aging
Alzheimer Disease
Amyloid beta-Protein Precursor
Apolipoproteins E
Brain
Choline O-Acetyltransferase
Cognition Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Primers

Disease Progression

Female

Gene Expression

Genotype

Glucose

Humans

Insulin

Source

Identifiers

PMID: 16340083
DOI: 10.3233/jad-2005-8304

Genes

AIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16340083-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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