Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuronal insulin signal transduction mechanisms in diabetes phenotypes.

Neurobiology of aging - 1 Dec 2005

Reagan Lawrence P

Abstract excerpt

The hippocampus is an important integration center for learning and memory in the mammalian central nervous system (CNS) and is particularly sensitive and responsive to changes in insulin and glucose concentrations. Insulin administration improves cognitive performance in a variety of physiological and pathophysiological settings, including diabetes phenotypes. Our previous studies demonstrated that hyperglycemia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus
Share to Disease Models, Animal
Share to Glucose Transport Proteins, Facilitative

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin

Share to Phenotype

Share to Signal Transduction

Source

Identifiers

PMID: 16225964
DOI: 10.1016/j.neurobiolaging.2005.09.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuronal insulin signal transduction mechanisms in diabetes phenotypes.PMID 16225964Read ↗

The role of endoplasmic reticulum stress in hippocampal insulin resistance.Semantic proximity Read ↗

Memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and BDNF signaling pathways in prediabetic mice.Semantic proximity Read ↗

Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes.Semantic proximity Read ↗

Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model.Semantic proximity Read ↗

Tau deletion promotes brain insulin resistanceSemantic proximity Read ↗

Epigenetic Alterations in Alzheimer’s Disease: Impact on Insulin Signaling and Advanced Drug Delivery SystemsSemantic proximity Read ↗

Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer’s knock-in mouse phenotypesSemantic proximity Read ↗

Insulin Resistance and Diabetes Mellitus in Alzheimer’s DiseaseSemantic proximity Read ↗

Loss of brain insulin production impairs learning and memory in female miceSemantic proximity Read ↗

Understanding the link between insulin resistance and Alzheimer’s disease: Insights from animal modelsSemantic proximity Read ↗

Loss of brain insulin production impairs learning and memory in female miceSemantic proximity Read ↗

Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.