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Article

Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 2023

Chen Wenqiang, Huang Qian, Lazdon Ekaterina Katie, Gomes Antonio, Wong Marisa, Stephens Emily, Royal Tabitha Grace, Frenkel Dan, Cai Weikang, Kahn C Ronald

Abstract excerpt

Brain insulin signaling controls peripheral energy metabolism and plays a key role in the regulation of mood and cognition. Epidemiological studies have indicated a strong connection between type 2 diabetes (T2D) and neurodegenerative disorders, especially Alzheimer's disease (AD), linked via dysregulation of insulin signaling, i.e., insulin resistance. While most studies have focused on neurons, here, we aim to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 37186836
DOI: 10.1073/pnas.2220684120
PMCID: PMC10214134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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