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Article

High-frequency modification of plant genes using engineered zinc-finger nucleases.

Nature - 21 May 2009

Townsend Jeffrey A, Wright David A, Winfrey Ronnie J, Fu Fengli, Maeder Morgan L, Joung J Keith, Voytas Daniel F

Abstract excerpt

An efficient method for making directed DNA sequence modifications to plant genes (gene targeting) is at present lacking, thereby frustrating efforts to dissect plant gene function and engineer crop plants that better meet the world's burgeoning need for food, fibre and fuel. Zinc-finger nucleases (ZFNs)-enzymes engineered to create DNA double-strand breaks at specific loci-are potent stimulators of gene...

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Identifiers

PMID: 19404258
DOI: 10.1038/nature07845
PMCID: PMC2743854

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