Trait stacking via targeted genome editing.

doi:10.1111/pbi.12107

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Article

Trait stacking via targeted genome editing.

Plant biotechnology journal - 1 Dec 2013

Ainley William M, Sastry-Dent Lakshmi, Welter Mary E, Murray Michael G, Zeitler Bryan, Amora Rainier, Corbin David R, Miles Rebecca R, Arnold Nicole L, Strange Tonya L, Simpson Matthew A, Cao Zehui, Carroll Carley, Pawelczak Katherine S, Blue Ryan, West Kim, Rowland Lynn M, Perkins Douglas, Samuel Pon, Dewes Cristie M, Shen Liu, Sriram Shreedharan, Evans Steven L, Rebar Edward J, Zhang Lei, Gregory Phillip D, Urnov Fyodor D, Webb Steven R, Petolino Joseph F

Abstract excerpt

Modern agriculture demands crops carrying multiple traits. The current paradigm of randomly integrating and sorting independently segregating transgenes creates severe downstream breeding challenges. A versatile, generally applicable solution is hereby provided: the combination of high-efficiency targeted genome editing driven by engineered zinc finger nucleases (ZFNs) with modular 'trait landing pads' (TLPs)...

Topics

Crops, Agricultural
Endonucleases
Gene Targeting
Genetic Linkage
Genome, Plant
Herbicide Resistance
Herbicides
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plant Leaves

Plant Proteins

Plants, Genetically Modified

Transgenes

Zea mays

Zinc Fingers

Source

Open in PubMed

Identifiers

PMID: 23953646
DOI: 10.1111/pbi.12107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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