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Article

Accounting for linkage in family-based tests of association with missing parental genotypes.

American journal of human genetics - 1 Nov 2003

Martin Eden R, Bass Meredyth P, Hauser Elizabeth R, Kaplan Norman L

Abstract excerpt

In studies of complex diseases, a common paradigm is to conduct association analysis at markers in regions identified by linkage analysis, to attempt to narrow the region of interest. Family-based tests for association based on parental transmissions to affected offspring are often used in fine-mapping studies. However, for diseases with late onset, parental genotypes are often missing. Without parental...

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PMID: 14551902
DOI: 10.1086/378779
PMCID: PMC1180482

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