Article
Oligogenic inheritance in severe adult obesity.
International journal of obesity (2005) - 1 Jun 2024
Almansoori Sumaya, Alsters Suzanne I, Yiorkas Andrianos M, Nor Hashim Nikman Adli, Walters Robin G, Chahal Harvinder S, Purkayastha Sanjay, Lessan Nader, Blakemore Alexandra I F
Abstract excerpt
BACKGROUND/OBJECTIVE: The genetic architecture of extreme non-syndromic obesity in adults remains to be elucidated. A range of genes are known to cause monogenic obesity, but even when pathogenic mutations are present, there may be variable penetrance. METHODS: Whole-exome sequencing (WES) was carried out on a 15-year-old male proband of Pakistani ancestry who had severe obesity. This was followed by family...
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